PoplarV1, Main, Exploration, bibRecord, 001886

Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs.

Identifieur interne : 001886 ( Main/Exploration ); précédent : 001885; suivant : 001887

Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs.

Auteurs : Robert H. Six [États-Unis] ; Thomas Geurden [Belgique] ; Raj Packianathan [Australie] ; Sally Colgan [Australie] ; William R. Everett [États-Unis] ; Sarah Grace [Irlande (pays)] ; Andrew Hodge [Australie] ; Sean P. Mahabir [États-Unis] ; Melanie R. Myers [États-Unis] ; Nathalie Slootmans [Belgique] ; Kylie Davis [Australie]

Source :

Veterinary parasitology [ 1873-2550 ] ; 2016.

RBID : pubmed:26935820

Descripteurs français

KwdFr :
- Administration par voie orale (MeSH), Animaux (MeSH), Chiens (MeSH), Femelle (MeSH), Infestations par les puces (médecine vétérinaire), Infestations par les puces (prévention et contrôle), Infestations par les puces (traitement médicamenteux), Insecticides (administration et posologie), Insecticides (normes), Isoxazoles (administration et posologie), Isoxazoles (normes), Maladies des chiens (prévention et contrôle), Maladies des chiens (traitement médicamenteux), Mâle (MeSH), Préparation de médicament (médecine vétérinaire), Préparation de médicament (normes), Résultat thérapeutique (MeSH).
MESH :
- administration et posologie : Insecticides, Isoxazoles.
- médecine vétérinaire : Infestations par les puces, Préparation de médicament.
- normes : Insecticides, Isoxazoles, Préparation de médicament.
- prévention et contrôle : Infestations par les puces, Maladies des chiens.
- traitement médicamenteux : Infestations par les puces, Maladies des chiens.
- Administration par voie orale, Animaux, Chiens, Femelle, Mâle, Résultat thérapeutique.

English descriptors

KwdEn :
- Administration, Oral (MeSH), Animals (MeSH), Dog Diseases (drug therapy), Dog Diseases (prevention & control), Dogs (MeSH), Drug Compounding (standards), Drug Compounding (veterinary), Female (MeSH), Flea Infestations (drug therapy), Flea Infestations (prevention & control), Flea Infestations (veterinary), Insecticides (administration & dosage), Insecticides (standards), Isoxazoles (administration & dosage), Isoxazoles (standards), Male (MeSH), Treatment Outcome (MeSH).
MESH :
- chemical , administration & dosage : Insecticides, Isoxazoles.
- drug therapy : Dog Diseases, Flea Infestations.
- prevention & control : Dog Diseases, Flea Infestations.
- standards : Drug Compounding, Insecticides, Isoxazoles.
- veterinary : Drug Compounding, Flea Infestations.
- Administration, Oral, Animals, Dogs, Female, Male, Treatment Outcome.

Abstract

The efficacy of a single oral dose of a novel isoxazoline, sarolaner (Simparica™, Zoetis), for the treatment and control of flea infestations on dogs was confirmed in five laboratory studies. The studies were conducted using adult purpose-bred Beagles and/or mixed breed dogs. All animals were individually identified and housed, and were allocated randomly to treatment with either placebo or sarolaner (eight to 10 per group) based on pretreatment parasite counts. Three studies used cat flea (Ctenocephalides felis felis) strains recently isolated from the field from the US, EU, or Australia; in the fourth study a laboratory strain (KS1) with documented tolerance to a number of insecticides such as fipronil, imidacloprid, and permethrin was used. In the fifth study, dogs were infested with dog fleas, Ctenocephalides canis. Dogs were treated orally on Day 0 with a placebo or a sarolaner tablet providing a minimum dose of 2mg/kg. Dogs were infested with approximately 100 unfed, adult fleas prior to treatment and at weekly intervals post-treatment. Comb counts were conducted to determine the numbers of viable fleas at 24h after treatment and after each subsequent infestation. Efficacy against C. felis and C. canis was 99.8-100% from treatment through Day 35. In all five studies, elimination of existing infestations was achieved within 24h after dosing, with only a single live C. felis found on one dog on Day 1. Similarly, control of flea challenges was achieved within 24h after infestation throughout the 35day study periods, with only single live C. felis found on two dogs on Day 28 in one study, and on a single dog on Day 35 in another study. There were no adverse reactions to treatment with sarolaner. These studies confirmed that a single oral dose of sarolaner at 2mg/kg provided highly effective treatment of existing C. felis infestations and persistent control of C. felis on dogs for 35days after treatment. Efficacy equivalent to that seen with C. felis was confirmed against C. canis and a known insecticide-tolerant strain of C. felis.

DOI: 10.1016/j.vetpar.2016.02.015
PubMed: 26935820

Affiliations:

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Le document en format XML

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<author><name sortKey="Colgan, Sally" sort="Colgan, Sally" uniqKey="Colgan S" first="Sally" last="Colgan">Sally Colgan</name>
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<author><name sortKey="Everett, William R" sort="Everett, William R" uniqKey="Everett W" first="William R" last="Everett">William R. Everett</name>
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<author><name sortKey="Grace, Sarah" sort="Grace, Sarah" uniqKey="Grace S" first="Sarah" last="Grace">Sarah Grace</name>
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<author><name sortKey="Mahabir, Sean P" sort="Mahabir, Sean P" uniqKey="Mahabir S" first="Sean P" last="Mahabir">Sean P. Mahabir</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Michigan</region>
</placeName>
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<author><name sortKey="Myers, Melanie R" sort="Myers, Melanie R" uniqKey="Myers M" first="Melanie R" last="Myers">Melanie R. Myers</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Slootmans, Nathalie" sort="Slootmans, Nathalie" uniqKey="Slootmans N" first="Nathalie" last="Slootmans">Nathalie Slootmans</name>
<affiliation wicri:level="1"><nlm:affiliation>Zoetis, Veterinary Medicine Research and Development, Hoge Wei 10, B-1930 Zaventem, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Davis, Kylie" sort="Davis, Kylie" uniqKey="Davis K" first="Kylie" last="Davis">Kylie Davis</name>
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<country xml:lang="fr">Australie</country>
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<series><title level="j">Veterinary parasitology</title>
<idno type="eISSN">1873-2550</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Dog Diseases (drug therapy)</term>
<term>Dog Diseases (prevention & control)</term>
<term>Dogs (MeSH)</term>
<term>Drug Compounding (standards)</term>
<term>Drug Compounding (veterinary)</term>
<term>Female (MeSH)</term>
<term>Flea Infestations (drug therapy)</term>
<term>Flea Infestations (prevention & control)</term>
<term>Flea Infestations (veterinary)</term>
<term>Insecticides (administration & dosage)</term>
<term>Insecticides (standards)</term>
<term>Isoxazoles (administration & dosage)</term>
<term>Isoxazoles (standards)</term>
<term>Male (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Chiens (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Infestations par les puces (médecine vétérinaire)</term>
<term>Infestations par les puces (prévention et contrôle)</term>
<term>Infestations par les puces (traitement médicamenteux)</term>
<term>Insecticides (administration et posologie)</term>
<term>Insecticides (normes)</term>
<term>Isoxazoles (administration et posologie)</term>
<term>Isoxazoles (normes)</term>
<term>Maladies des chiens (prévention et contrôle)</term>
<term>Maladies des chiens (traitement médicamenteux)</term>
<term>Mâle (MeSH)</term>
<term>Préparation de médicament (médecine vétérinaire)</term>
<term>Préparation de médicament (normes)</term>
<term>Résultat thérapeutique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Insecticides</term>
<term>Isoxazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Insecticides</term>
<term>Isoxazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dog Diseases</term>
<term>Flea Infestations</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infestations par les puces</term>
<term>Préparation de médicament</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Insecticides</term>
<term>Isoxazoles</term>
<term>Préparation de médicament</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dog Diseases</term>
<term>Flea Infestations</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infestations par les puces</term>
<term>Maladies des chiens</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Drug Compounding</term>
<term>Insecticides</term>
<term>Isoxazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infestations par les puces</term>
<term>Maladies des chiens</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Drug Compounding</term>
<term>Flea Infestations</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Dogs</term>
<term>Female</term>
<term>Male</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term>
<term>Animaux</term>
<term>Chiens</term>
<term>Femelle</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">The efficacy of a single oral dose of a novel isoxazoline, sarolaner (Simparica™, Zoetis), for the treatment and control of flea infestations on dogs was confirmed in five laboratory studies. The studies were conducted using adult purpose-bred Beagles and/or mixed breed dogs. All animals were individually identified and housed, and were allocated randomly to treatment with either placebo or sarolaner (eight to 10 per group) based on pretreatment parasite counts. Three studies used cat flea (Ctenocephalides felis felis) strains recently isolated from the field from the US, EU, or Australia; in the fourth study a laboratory strain (KS1) with documented tolerance to a number of insecticides such as fipronil, imidacloprid, and permethrin was used. In the fifth study, dogs were infested with dog fleas, Ctenocephalides canis. Dogs were treated orally on Day 0 with a placebo or a sarolaner tablet providing a minimum dose of 2mg/kg. Dogs were infested with approximately 100 unfed, adult fleas prior to treatment and at weekly intervals post-treatment. Comb counts were conducted to determine the numbers of viable fleas at 24h after treatment and after each subsequent infestation. Efficacy against C. felis and C. canis was 99.8-100% from treatment through Day 35. In all five studies, elimination of existing infestations was achieved within 24h after dosing, with only a single live C. felis found on one dog on Day 1. Similarly, control of flea challenges was achieved within 24h after infestation throughout the 35day study periods, with only single live C. felis found on two dogs on Day 28 in one study, and on a single dog on Day 35 in another study. There were no adverse reactions to treatment with sarolaner. These studies confirmed that a single oral dose of sarolaner at 2mg/kg provided highly effective treatment of existing C. felis infestations and persistent control of C. felis on dogs for 35days after treatment. Efficacy equivalent to that seen with C. felis was confirmed against C. canis and a known insecticide-tolerant strain of C. felis. </div>
</front>
</TEI>
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<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2550</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>222</Volume>
<PubDate><Year>2016</Year>
<Month>May</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>Veterinary parasitology</Title>
<ISOAbbreviation>Vet Parasitol</ISOAbbreviation>
</Journal>
<ArticleTitle>Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs.</ArticleTitle>
<Pagination><MedlinePgn>18-22</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vetpar.2016.02.015</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0304-4017(16)30037-1</ELocationID>
<Abstract><AbstractText>The efficacy of a single oral dose of a novel isoxazoline, sarolaner (Simparica™, Zoetis), for the treatment and control of flea infestations on dogs was confirmed in five laboratory studies. The studies were conducted using adult purpose-bred Beagles and/or mixed breed dogs. All animals were individually identified and housed, and were allocated randomly to treatment with either placebo or sarolaner (eight to 10 per group) based on pretreatment parasite counts. Three studies used cat flea (Ctenocephalides felis felis) strains recently isolated from the field from the US, EU, or Australia; in the fourth study a laboratory strain (KS1) with documented tolerance to a number of insecticides such as fipronil, imidacloprid, and permethrin was used. In the fifth study, dogs were infested with dog fleas, Ctenocephalides canis. Dogs were treated orally on Day 0 with a placebo or a sarolaner tablet providing a minimum dose of 2mg/kg. Dogs were infested with approximately 100 unfed, adult fleas prior to treatment and at weekly intervals post-treatment. Comb counts were conducted to determine the numbers of viable fleas at 24h after treatment and after each subsequent infestation. Efficacy against C. felis and C. canis was 99.8-100% from treatment through Day 35. In all five studies, elimination of existing infestations was achieved within 24h after dosing, with only a single live C. felis found on one dog on Day 1. Similarly, control of flea challenges was achieved within 24h after infestation throughout the 35day study periods, with only single live C. felis found on two dogs on Day 28 in one study, and on a single dog on Day 35 in another study. There were no adverse reactions to treatment with sarolaner. These studies confirmed that a single oral dose of sarolaner at 2mg/kg provided highly effective treatment of existing C. felis infestations and persistent control of C. felis on dogs for 35days after treatment. Efficacy equivalent to that seen with C. felis was confirmed against C. canis and a known insecticide-tolerant strain of C. felis. </AbstractText>
<CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Six</LastName>
<ForeName>Robert H</ForeName>
<Initials>RH</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 333 Portage St. Kalamazoo, MI 49007, USA. Electronic address: robert.six@Zoetis.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Geurden</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, Hoge Wei 10, B-1930 Zaventem, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Packianathan</LastName>
<ForeName>Raj</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 45 Poplar Road, Parkville, VIC 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Colgan</LastName>
<ForeName>Sally</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>SCEC Pty Ltd., P.O. Box 211, Northbridge, NSW 1560, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Everett</LastName>
<ForeName>William R</ForeName>
<Initials>WR</Initials>
<AffiliationInfo><Affiliation>BerTek, Inc., P.O. Box 606, Greenbrier, AR 72058, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grace</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Charles River Laboratories, Pre-Clinical Services, Glenamoy, Co., Mayo, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hodge</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 45 Poplar Road, Parkville, VIC 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahabir</LastName>
<ForeName>Sean P</ForeName>
<Initials>SP</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 333 Portage St. Kalamazoo, MI 49007, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Myers</LastName>
<ForeName>Melanie R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 333 Portage St. Kalamazoo, MI 49007, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slootmans</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, Hoge Wei 10, B-1930 Zaventem, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davis</LastName>
<ForeName>Kylie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Zoetis, Veterinary Medicine Research and Development, 45 Poplar Road, Parkville, VIC 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Vet Parasitol</MedlineTA>
<NlmUniqueID>7602745</NlmUniqueID>
<ISSNLinking>0304-4017</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007306">Insecticides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007555">Isoxazoles</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004283" MajorTopicYN="N">Dog Diseases</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004339" MajorTopicYN="N">Drug Compounding</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058267" MajorTopicYN="N">Flea Infestations</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007306" MajorTopicYN="N">Insecticides</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007555" MajorTopicYN="N">Isoxazoles</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ctenocephalides canis</Keyword>
<Keyword MajorTopicYN="N">Ctenocephalides felis felis</Keyword>
<Keyword MajorTopicYN="N">Dog</Keyword>
<Keyword MajorTopicYN="N">Dose confirmation</Keyword>
<Keyword MajorTopicYN="N">Flea</Keyword>
<Keyword MajorTopicYN="N">Isoxazoline</Keyword>
<Keyword MajorTopicYN="N">KS1</Keyword>
<Keyword MajorTopicYN="N">Oral</Keyword>
<Keyword MajorTopicYN="N">Sarolaner</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>10</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>12</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>02</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>3</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>12</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26935820</ArticleId>
<ArticleId IdType="pii">S0304-4017(16)30037-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.vetpar.2016.02.015</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Irlande (pays)</li>
<li>États-Unis</li>
</country>
<region><li>Arkansas</li>
<li>Michigan</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Michigan"><name sortKey="Six, Robert H" sort="Six, Robert H" uniqKey="Six R" first="Robert H" last="Six">Robert H. Six</name>
</region>
<name sortKey="Everett, William R" sort="Everett, William R" uniqKey="Everett W" first="William R" last="Everett">William R. Everett</name>
<name sortKey="Mahabir, Sean P" sort="Mahabir, Sean P" uniqKey="Mahabir S" first="Sean P" last="Mahabir">Sean P. Mahabir</name>
<name sortKey="Myers, Melanie R" sort="Myers, Melanie R" uniqKey="Myers M" first="Melanie R" last="Myers">Melanie R. Myers</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Geurden, Thomas" sort="Geurden, Thomas" uniqKey="Geurden T" first="Thomas" last="Geurden">Thomas Geurden</name>
</noRegion>
<name sortKey="Slootmans, Nathalie" sort="Slootmans, Nathalie" uniqKey="Slootmans N" first="Nathalie" last="Slootmans">Nathalie Slootmans</name>
</country>
<country name="Australie"><noRegion><name sortKey="Packianathan, Raj" sort="Packianathan, Raj" uniqKey="Packianathan R" first="Raj" last="Packianathan">Raj Packianathan</name>
</noRegion>
<name sortKey="Colgan, Sally" sort="Colgan, Sally" uniqKey="Colgan S" first="Sally" last="Colgan">Sally Colgan</name>
<name sortKey="Davis, Kylie" sort="Davis, Kylie" uniqKey="Davis K" first="Kylie" last="Davis">Kylie Davis</name>
<name sortKey="Hodge, Andrew" sort="Hodge, Andrew" uniqKey="Hodge A" first="Andrew" last="Hodge">Andrew Hodge</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Grace, Sarah" sort="Grace, Sarah" uniqKey="Grace S" first="Sarah" last="Grace">Sarah Grace</name>
</noRegion>
</country>
</tree>
</affiliations>
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Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs.

Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs.

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